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SPS-1

SPS-1 (UW solution) is a clear to light yellow,sterile,non-pyrogenic solution for hypothermic flushing , storage and transportation of isolated abdominal organs.

COMPOSITION:

The solution has an osmolality of 310 +or_ 15 mOsm/kg. 29 mEq/l, 125 mEq/l concentration of sodium and potassium respectively and a pH of 7.4 at 20o c.

  • Pentafraction -50 g
  • lactone - 35.83g
  • Potassium phosphate monobasic-3.4g
  • Magnesium sulphate heptahydrate -1.23g
  • Raffinose pentahydrate -17.83g
  • Adenosine -1.34g
  • Allopurinol -0.136g
  • Glutathione -0.922g
  • Potassium hydroxide -5.61g
  • Sodium hydroxide/Hydrochloric acid - adjust to pH-7.4
  • Sterile water - to 1000ml vol

INDICATIONS AND CLINICAL USES :

SPS-1 must be cooled to 2 – 60c prior to use. The solution is flushed into the isolated organ before/after removal of organ. The solution is left in the organ vasculature during the hypothermic storage and transportation. SPS-1 is to be used for cold storage of the organ but not acceptable for continuous machine perfusion.

SUGGESTED MINIMUM VOLUMES:

In situ aortic flush Adults: 2-4L
Infants :50 ml/kg
In VIVIO infusion Liver - Adults: 1200 ml

Infants :50 ml/kg

Pancreas - Adults: 300-500ml

Infants :150-250 ml

STORAGE AND SHELF LIFE:

It can be stored at ambient temperature and cooled to 2 – 6o c prior to use.

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