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It is used in the diagnosis of premature rupture of fetal membranes (PROM) using biomarkers Insulin Growth Factor Binding Protein-1 (IGFBP-1) and Alfa Feto Protein (AFP) from vaginal fluid swab.
Usage timings: From 24 weeks of pregnancy to the complete gestation period.
IGFBP-1: Biomarker related to premature rupture of fetal membranes.
AFP: Biomarker related to genetic abnormality.