Lifeport Liver transporter

LIFEPORT LIVER TRANSPORTER

Approximately 2,500 patients in the United States die every year on the liver transplant waiting list before a donor liver becomes available. Increasing the number of organs available for transplantation, while reducing post-transplantation complications and shortening the length of hospital stay, are important clinical goals to improve patient outcomes.

Almost 2,500 adult patients die in th US each year waiting for a liver transplant

	2010	2011	2012
Patients at start of year	14,956	15,360	15,428
Patients added during year	10,349	10,359	10,143
Patients removed during year	9,925	10,272	10281
Patinets at end of year	15,380	15,447	15,290
Removal reason	0.068 g	0.5	0.5
Deceased donor transplant	5,450	5,539	5,468
Living donor transplant	209	187	192
Patient died	2,458	2506	2,187
Patient refused transplant	53	60	73
Improved,transplant not needed	552	541	644
Too sick to transplant	362	482	815
Other	841	957	902

HMP reduces the impact of liver injury compared with SCS

Marker	HMP	SCS	Pvalue
peakserum AST	1154 IU/mL	3339 IU/mL	0.011
Peakserum ALT	560 IU/mL	1358 IU/mL	0.044
Peakserum TBili	6.59mg/dL	9.46mg/dL	0.042
Peakserum SCr	1.34mg/dL	2.00mg/dL	0.013

Transforming Outcomes

A controlled clinical feasibility study at Columbia University Medical Center/New York Presbyterian Hospital using a prototype LifePort Liver Transporter system found 50 percent fewer patients had biliary complications with LifePort-perfused livers. Early allograft dysfunction was seen in 25 percent of static cold stored livers compared with 5 percent of LifePort-perfused livers (p = 0.08).2Additionally, patients receiving LifePort perfused livers had a significantly lower length of hospital stay than patients with static cold stored livers (10.9 ± 4.7 days vs. 15.3 ± 4.9 days; p = 0.006).

A second controlled study investigated hypothermic machine preservation versus static cold storage of expanded criteria livers rejected by the originating UNOS region.3 During 12-months post transplantation there were significantly fewer biliary complications in the perfused group (4 vs. 13, respectively; p = 0.016), and early allograft dysfunction rates were also lower (19% vs. 30%). Mean hospital stay was also significantly shorter in the perfused group (13.6 vs. 21.1 days). The results suggest that hypothermic machine perfusion (HMP) of livers is safe and allows for transplantation of expanded criteria livers deemed untransplantable by multiple centers. Study investigators concluded that HMP has the potential to increase the donor pool and the availability of livers for patients on the waiting list.

LifePort Liver Transporter is in the process of securing US and European regulatory registrations. Its design, engineering and performance capabilities are based upon the LifePort prototype system used in the Columbia University Medical Center/ New York Presbyterian Hospital, and the proven technology platform of the market leading LifePort Kidney Transporter.

Innovative LifePort technology

LifePort Liver Transporter is designed to deliver precision controlled perfusion of the hepatic artery and portal vein. Hypothermic perfusion is supported by redundant preservation systems for safety – dynamic perfusion plus static cold storage.

Programmable display

The clear programmable interface displays key data that track real-time organ perfusion status, patient ID number and blood type, cross clamp and total infusion time, perfusate temperature, hepatic and portal flow and pressure and total flow.

Fold-out work surfaces

LifePort Liver Transporter's lid folds out to provide an optional work surface for crowded OR suites. The work surfaces lids are hinged for easy removal and storage.

Optional custom adjustable cart

The height-adjustable fold-flat cart seamlessly docks with LifePort Liver Transporter, and is designed to provide optimal surgeon comfort and optical range.

Clinical experience of LifePort Liver Transporter

Watch Dr. James V. Guarrera, Associate Professor of Surgery, Surgical Director of Adult Liver Transplantation, Columbia University Medical Center/New York Presbyterian Hospital, NY, USA, discuss his experience with hypothermic machine perfusion of livers for clinical transplantation

Full Summary of the Clinical Experience for LifePort Liver Transporter › Caution—Investigational Device. Limited by Federal law to investigational use. Registrations underway in US and EU.